Sialyl-lewis x
WebApr 15, 2006 · CLA defines a subset of human peripheral helper memory T cells and has long been used as a specific carbohydrate determinant in characterizing skin-homing helper memory T-cell populations. 5 The HECA-452 antibody defining CLA was shown to recognize the sialyl Lewis X (Le x) determinant, which is known as a typical carbohydrate ligand for ... WebApr 8, 2024 · In addition, sialyl Lewis X and sialyl Lewis a are also known to be the ligands of selectins that are a family of cell-adhesion molecules expressed on endothelial cells, leukocytes and platelets.
Sialyl-lewis x
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WebSialyl-Lewis X. SLeX is a key recognition determinant for selectins that allow endothelial cells to recruit lymphocytes to roll on the endothelium prior to extravasation into tissues. … WebWe find that beads coated with the saccharides sialyl Lewis (x) (sLe (x)), sialyl Lewis (a) (sLe (a)), and sulfated Lewis (x) (HSO (3)Le (x) support rolling adhesion on P-selectin …
Webformer of the sialyl Lewis x exists in aqueous solution [5, 7, 9, 12]. These conclusions are controversial with some experimental and molecular modelling data [15, WebSelectins bind to the sialyl Lewis X (SLe x) determinant “NeuAcα2-3Galβ1-4(Fucα1-3)GlcNAc.” However, SLe x, per se, does not constitute an effective selectin receptor. …
WebJun 6, 2024 · The sialyl Lewis X (SLe x) antigen encoded by the FUT7 gene is the ligand of endotheliam-selectin (E-selectin).The combination of SLe x antigen and E-selectin represents an important way for malignant tumor metastasis. In the present study, the effect of the SLe x-binding DNA aptamer on the adhesion and metastasis of hepatocellular … WebWe investigated the expression of a number of mucin core proteins and associated O-linked glycans expressed in pancreatic adenocarcinoma-sialyl Tn (STn), Tn, T antigen, sialyl Lewis A (CA19-9), sialyl Lewis C (SLeC), Lewis X (LeX), and sialyl LeX (SLeX)-during the progression of pancreatic cancer from early stages to metastatic disease.
WebJan 18, 2024 · Among the best described ligands for the selectins are derivatives of the fucosylated and sialylated tetrasaccharides sialyl Lewis x (sLe x, …
WebIt has been established that sialyl Lewis x in core 2 branched O-glycans serves as an E- and P-selectin ligand. Recently, it was discovered that 6-sulfosialyl Lewis x in extended core 1 O-glycans, NeuNAcα2→3Galβ1→4(Fucα1→3(sulfo→6))GlcNAcβ1→ 3Galβ1→3GalNAcα1→Ser/Thr, functions as an L-selectin ligand in high endothelial … sibley epicSialyl Lewis (sLeX), also known as cluster of differentiation 15s (CD15s) or stage-specific embryonic antigen 1 (SSEA-1), is a tetrasaccharide carbohydrate which is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes. It is also the means by which … See more Sialyl-Lewis X is a tetrasaccharide composed of a sialic acid, fucose and an N-acetyllactosamine. Its systematic name is 5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine (Neu5Acα2-3Galβ1 … See more Leukocyte homing Sialyl-Lewis is important in leukocyte tethering and rolling. Leukocytes move through the blood stream and then tether themselves to the … See more The term Lewis in its name comes from the name of a family of people who suffered from a red blood cell incompatibility. The studies done on these individuals' red … See more Leukocyte adhesion deficiency Defective synthesis of the sialyl Lewis antigen results in immunodeficiency (leukocyte adhesion deficiency type 2). Defective synthesis can be caused by the loss of fucosyltransferase, impairing the glycosylation of the … See more • CA19-9 (Sialyl-Lewis A) See more • Chen, G.-Y.; Osada, H.; Santamaria-Babi, L. F.; Kannagi, R. (7 November 2006). "Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes" See more the perfect american familyWebOct 21, 2024 · The impact of glycosylation on cell behavior largely depends on the terminal portions of glycoconjugates. Examples of terminal structures include α2,3- and α2,6-linked … the perfect americanWebSialyl-Lewis X C31H52N2O23 CID 643990 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... the perfect american philip glassWebFree anomeric carbon of GlcNAc3 is not required for the interaction between SabA and Sialyl Lewis x antigen. 10,16 Gonçalves et al 17 developed chitosan microspheres coated with Lewis b and Sialyl Lewis x and demonstrated that these microspheres are able to prevent H. pylori adhesion to gastric epithelial cells in an in vitro and ex vivo model. sibley evusheldWebCD15s (sialyl Lewis x), a tetrasaccharide carbohydrate, is the α2-3 sialylated form of lacto-N-fucopentaose III (CD15) . In addition to eTreg cells and some memory and/or activated T cells, CD15s is highly expressed on … the perfect alibi movieWebSialyl-Lewis x (s-Le x)-bearing species have been selected from plasma with the monoclonal antibody CHO-131.This antibody selects s-Le x antigen at points of branching in which the GlcNAc residue of s-Le x is coupled in a β-(1,6) linkage. 60 At N-linked glycosylation sites, s-Le x is conjugated to the glycan matrix through a -GlcNAc-β-(1,6)-Man- linkage and … sibley estate agents scilly