WebFragile X Mental Retardation Protein (FMRP) is an RNA-binding protein that plays an essential role in cognitive brain function. Mutations in the FMR1 gene, which codes for FMRP, can result in fragile X syndrome, autism, as well as other cognitive deficits (Brown et al.,1998, Goodlin-Jones et al., 2004). WebOct 1, 2024 · The Fragile-X Mental Retardation Protein (FMRP) is an RNA binding protein that regulates translation of mRNAs essential for synaptic development and plasticity. FMRP interacts with a specific set of mRNAs, aids in their microtubule-dependent transport and regulates their translation through its association with ribosomes.
Phosphorylation influences the translation state of FMRP …
WebSep 8, 2016 · Phosphorylation of CaMKII at T286 has been implicated in a number of neuronal processes, and has been shown to be essential for the acquisition of fear and spatial learning 7, 20, 21. However,... WebN-Glycosylation, O-GlcNAcylation and Phosphorylation Modification of Proteins From Melanoma Cell Lineages Melo, ... 1Molecular & Cell Biology, FMRP-USP-Ribeirao Preto 2Experimental Oncology, FM-USP, Sao Paulo, Brazil. Melanoma is an aggressive tumor derived by transformation of melanocytes due to changing in skin microenvironment. We ... dialysis access center corpus christi tx
The molecular biology of FMRP: new insights into fragile …
WebOther articles where FMRP is discussed: fragile-X syndrome: …of a protein known as FMRP (fragile-X mental retardation protein). FMRP plays an important role in the brain, … WebFeb 19, 2024 · In addition, studies have shown that phosphorylation levels in the carboxy-terminal region of FMRP regulate both its phase separation into liquid droplets by way of its intrinsically disordered ... WebDec 26, 2007 · Here, we identify protein phosphatase 2A (PP2A) as an FMRP phosphatase and report rapid FMRP dephosphorylation after immediate group I metabotropic … cipher\u0027s 1h